Sustainability analysis of the CITYLAB solutions

The objective of the CITYLAB project is to develop knowledge and solutions that result in roll-out, upscaling and further uptake of cost effective strategies, measures and tools for emission free city logistics. CITYLAB includes a set of Living Laboratories where promising logistic concepts are implemented related to emissions free city logistics. The objective of this report is to assess the impact that would occur when the CITYLAB implementations would be scaled up. The main challenge that has to be overcome is the difference in type, availability and detail of data from different CITYLAB implementations. This assessment of the impacts of upscaling is done by integrating all stakeholders’ opinions in the evaluation process and taking into account the costs and benefits for society as well as the financial viability for industry partners

Impact and process assessment of the seven CITYLAB implementations

CITYLAB focuses on four axes that call for improvement and intervention: •Highly fragmented last-mile deliveries in city centres •Inefficient deliveries to large freight attractors and public administrations •Urban waste, return trips and recycling •Logistics sprawl Within these axes, the project supports seven implementations that are being tested, evaluated and rolled out. An implementation is defined as the process of preparing, testing and putting into practice a new service or a new way of operating or organising logistics activities. The objective of this report is to present an assessment of the effects and consequences of the implementations as they are conducted. For each case, we summarise the process leading to the application of a specific technical and managerial solution, and present the outcomes. For each implementation, we present •Problem and aim •Description of the solution •Implementation process •Effects and consequences •Challenges ahead •Lessons and generalisation of results This deliverable provides a complete picture of the evolvement of the implementations during the CITYLAB project and final versions of the process and impact assessment

Using least median of squares for structural superposition of flexible proteins

<p>Abstract</p> <p>Background</p> <p>The conventional superposition methods use an ordinary least squares (LS) fit for structural comparison of two different conformations of the same protein. The main problem of the LS fit that it is sensitive to outliers, i.e. large displacements of the original structures superimposed.</p> <p>Results</p> <p>To overcome this problem, we present a new algorithm to overlap two protein conformations by their atomic coordinates using a robust statistics technique: least median of squares (LMS). In order to effectively approximate the LMS optimization, the forward search technique is utilized. Our algorithm can automatically detect and superimpose the rigid core regions of two conformations with small or large displacements. In contrast, most existing superposition techniques strongly depend on the initial LS estimating for the entire atom sets of proteins. They may fail on structural superposition of two conformations with large displacements. The presented LMS fit can be considered as an alternative and complementary tool for structural superposition.</p> <p>Conclusion</p> <p>The proposed algorithm is robust and does not require any prior knowledge of the flexible regions. Furthermore, we show that the LMS fit can be extended to multiple level superposition between two conformations with several rigid domains. Our fit tool has produced successful superpositions when applied to proteins for which two conformations are known. The binary executable program for Windows platform, tested examples, and database are available from <url>https://engineering.purdue.edu/PRECISE/LMSfit</url>.</p

DESA1002 'Nine Quarter City' - <Daniel Quach>

My Design project is a music store/performance area. I chose this because Madrid is a very culturally diverse city and so I wanted to express some of this in the form of music. By having a music store as well as performance areas, not only is the art of music encouraged, but sharing the creations of music is also promoted. The cladding of the building is made of bronze and has a very curvy look. This is to not only imitate the shape of a musical instrument but also represents the flow and waves of music. The shape also provides for a balcony for the 1st and 2nd floor of the music store. The building is made up two areas, the store and the performance areas. The store component has three levels which are accessed through a stairwell. Similarly there are three performance areas. The first performance space is on the ground floor and is accessible from the entrance without entering the store itself. This is because this performance area is more geared towards formal musical performances and so any night time performances have easy access On the first floor up and past the store area, there is a courtyard. This is the second performance space which allows for people to try out instruments (from the store racks) and perhaps share the music with any other musicians. The third performance space is a rooftop stage. This is also on the first floor and the stage itself overlooks the storefront. This space is designed to be the most expressive out of the three as performers would not only share music for those seated on that floor, but also anyone who passes by on street level. The stage can also be seen from balconies from the 2nd floor

Genomic insights into methanotrophy: The complete genome sequence of Methylococcus capsulatus (Bath)

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